A COVID-19 vaccine is administered in Toronto on Monday, Dec. 14, 2020. THE CANADIAN PRESS/Frank Gunn

A COVID-19 vaccine is administered in Toronto on Monday, Dec. 14, 2020. THE CANADIAN PRESS/Frank Gunn

Clinical trials start for Canadian COVID-19 vaccine candidate

Dubbed COVAC-2, the vaccine hopeful was developed by the Vaccine and Infectious Disease Organization

Clinical trials have begun for another Canadian-made COVID-19 vaccine candidate, with three people receiving an initial dose on Wednesday.

The Canadian Center for Vaccinology says the first of 108 healthy adult volunteers received injections in Halifax. The placebo-controlled study will administer two doses to each volunteer, 28 days apart.

“It’s a product of Canadian science, so it bodes well for the ability to make vaccines here. We all want to have vaccine manufacturing capacity in Canada,” said Dr. Joanne Langley, a vaccine researcher with the centre.

She said that the pace of testing is careful, as different age groups, from younger to older, receive varying doses in a process that will unfold over the next two months.

Dubbed COVAC-2, the vaccine hopeful was developed by the Vaccine and Infectious Disease Organization, or VIDO, at the University of Saskatchewan in Saskatoon.

It’s the first of two subunit vaccines by VIDO to enter clinical testing. Subunit vaccines contain purified viral proteins that are not infectious, and employ technology already used in vaccines for hepatitis, diphtheria, and whooping cough.

Darryl Falzarano, a vaccine researcher at VIDO, said he’s hoping that his institute’s promising tests on ferrets and hamsters will translate into safe and effective results in the human testing phase.

“Safety is the primary indicator (in the first phase) but you will also be looking at immune response,” he said.

Langley said the testing in the first phase is to determine safety to humans, and the participants will keep a diary that measure any pain or redness of the arm. The trial will also measure antibody responses, she said.

The next step would be to do trials at multiple sites around the country.

It is only in Phase 3 that the vaccine is compared against a placebo or another vaccine to see how well it protects against COVID-19, said Langley.

She said the entire vaccine testing process, if all went well, could take about nine months, adding that is a “very wishful, optimistic scenario.”

VIDO has said in a news release the product doesn’t need ultra-cold storage temperatures like synthetic messenger RNA or mRNA products. The two Health Canada-approved vaccines by Moderna and Pfizer-BioNTech each require special distribution and storage procedures that have complicated their rollout.

It follows the launch last month of clinical trials for a prospective vaccine by Calgary’s Providence Therapeutics, and last year’s launch of trials for a vaccine hopeful by Quebec City’s Medicago.

VIDO’s vaccine antigen – a molecule that triggers an immune response – was produced at Quebec-based Biodextris using a cell line from the National Research Council of Canada.

Development help also came from partners around the world, including Seppic in France and the Vaccine Formulation Institute in Switzerland.

At the same time, VIDO is building a manufacturing facility on the USask campus that could produce up to 40 million vaccine doses, but it wasn’t certain if that would include VIDO’s product. Construction is expected to be completed late this year.

Falzarano said the team in Saskatoon is excited the process is beginning, as this form of vaccine can be mass produced at a rapid rate if successful.

“It’s only the beginning of a multi-step process, but at least we’ve gotten to this milestone,” he said.

ALSO READ: Experts say race for COVID drugs dogged by false promises, lack of co-ordination

Michael Tutton and Cassandra Szklarski, The Canadian Press


Like us on Facebook and follow us on Twitter.

Want to support local journalism during the pandemic? Make a donation here.

Coronavirusvaccines

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

Surrey Police Service cruiser. (File photo)
Surrey Police Service, CUPE sign staff transfer agreement from RCMP to new force

Chief Constable says there will be ‘no disruption’ to police service during transfer

Seed & Stone hopes to open a cannabis retail store in the old Giraffe Restaurant building on White Rock’s waterfront. (Seed & Stone rendering).
Council to decide on cannabis store proposed for White Rock beach

Councillors heard support and opposition at public hearing last week

SkyTrain running through Whalley. (File photo: Tom Zytaruk)
Mayors’ Council wants feds to fund Surrey-Langley SkyTrain in upcoming budget

Mayors’ Council on regional transportation sent letter to federal government Monday

Spring Break kits available for free at Surrey Libraries branches. (submitted photo)
Free ‘Spring Break Kits’ for kids at Surrey Libraries

Children don’t need a library card to get a kit, but can sign up for one for free

An immunizer prepares to deliver a COVID-19 vaccine at a Fraser Health drive-thru vaccination site. (Fraser Health Authority photo)
North Delta COVID-19 vaccination clinic to open ‘in the coming weeks’

Clinic next to Delta City Hall opens March 15 for seniors 90+, Indigenous people 65+, Indigenous Elders

An animated Gordie Hogg introduces his 'Community Connections' videos. (YouTube screenshot)
Community Connections: Gordie Hogg speaks with Denise Stevenson

Former mayor, MP began posting conversations on YouTube in June

Cottonwoods Care Home in Kelowna. (Google Maps)
New COVID-19 outbreak at Kelowna care home includes fully vaccinated seniors: Henry

Two staff and 10 residents tested positive at Cottonwoods Care Centre

Excerpts from a conversation between Bria Fisher and the fake truLOCAL job. Fisher had signed a job agreement and was prepared to start work for what she thought was truLOCAL before she learned it was a scam. (Contributed)
B.C. woman warning others after losing $3,000 in job scam

Bria Fisher was hired by what she thought was a Canadian company, only to be out thousands

Some of the hundreds of pounds of trash removed by divers last month from Abbotsford’s Walmsley Lake.(Henry Wang photo)
VIDEO: Divers remove 462 pounds of trash from Abbotsford lake

Walmsley Lake dive uncovers several tires, hundreds of drink containers and a tent

Cannabis bought in British Columbia (Ashley Wadhwani/Black Press Media)
Is it time to start thinking about greener ways to package cannabis?

Packaging suppliers are still figuring eco-friendly and affordable packaging options that fit the mandates of Cannabis Regulations

Trent Miner is returning to the Vancouver Giants, the team announced. He has been released by the Colorado Eagles of the AHL.(Rik Fedyck/Vancouver Giants)
Trent Miner returns to play goal for Vancouver Giants

Netminder was part of epic 11-game winning-streak by Langley-based team

Provincial health officer Dr. Bonnie Henry and Health Minister Adrian Dix provide a regular update on the COVID-19 situation, B.C. legislature, March 2, 2020. (B.C. government)
B.C.’s COVID-19 cases: 545 Saturday, 532 Sunday, 385 Monday

Focus on Prince Rupert, Lower Mainland large workplaces

Rising accident rates and payout costs have contributed to billion-dollar deficits at ICBC. (Comox Valley Record)
B.C. appealing decision keeping ICBC injury cases in court

David Eby vows to ‘clip wings’ of personal injury lawyers

Most Read