Dylan Dyke, a 12-year-old boy with autism, spends time with his ducks, Nibbles, left, and Bill, outside his home in Michigan on Aug. 2, 2018. (Cory Morse/The Grand Rapids Press via AP)

Dylan Dyke, a 12-year-old boy with autism, spends time with his ducks, Nibbles, left, and Bill, outside his home in Michigan on Aug. 2, 2018. (Cory Morse/The Grand Rapids Press via AP)

Infants should be tested for autism if older siblings are diagnosed, Canadian study suggests

Blood test for infants with sibling who’s been diagnosed would get information to families earlier

Canadian researchers have led a study suggesting infants be tested for autism spectrum disorder before symptoms appear if an older sibling has already been diagnosed with the neurobiological condition.

The odds of a younger sibling having autism are up to 20 per cent, but most children miss out on early intervention for challenges in behaviour and communication because they’re often not diagnosed until age four, previous studies have shown.

Research by Dr. Stephen Scherer, senior scientist and director of the Centre for Applied Genomics at the Hospital for Sick Children in Toronto, and Dr. Lonnie Zwaigenbaum, a professor of pediatrics at the University of Alberta, found a standard blood test analyzing the DNA of infants with a sibling who’s been diagnosed with autism would provide earlier information for families.

The findings were published Thursday in the journal Nature Communications.

They involve 288 infant siblings from Canada and the United States showing that by age three, 157 of the children were either diagnosed with autism spectrum disorder or developing atypically. Of the 157 children, seven per cent were carrying a gene that put them at a very high risk of developing autism.

RELATED: New study suggests autism overdiagnosed, Canadian expert says

Of the seven per cent of kids, 50 per cent were diagnosed with autism by age three and an additional 35 per cent had other developmental challenges.

Scherer said families of autistic children are often concerned about whether a sibling could also be at risk.

“It’s the number one question families have and no one’s ever wrapped any statistics around that and that’s what we present for the first time, with this paper,” he said.

Further genetic testing looking at the entire genome, beyond a blood test called microarray analysis, is being conducted with all the families in the study in hopes it will provide more information about the risk of autism, Scherer said.

The participants were part of the Baby Siblings Research Consortium, which includes independent research groups in Canada, the United States and Europe, though this study included 10 sites in North America, four of them in Canada, Zwaigenbaum said of the testing that is part of an ongoing decade-long research project looking at behavioural predictors of autism.

“Based on the findings of the study, we’re suggesting that the test be focused on younger siblings,” he said. “It could be informative at a time where we’re not likely to see any behavioural signs. So it provides an option for presymptomatic testing to identify infants at highest risk.”

READ MORE: Autism support dog refused bus access for being a ‘pet’

Families who are informed about a younger child’s risk of autism could initiate strategies to help them develop early communication skills before assessment of behaviour by a specialist and intervention by a therapist as part of a cost-effective approach to care, Zwaigenbaum said.

“I think we may be moving to an exciting new time where both biomarkers and developmental surveillance can provide complementary information to help us identify infants at risk.”

Camille Bains, The Canadian Press

Like us on Facebook and follow us on Twitter

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

South Surrey’s Historic Stewart Farm. (City of Surrey photo)
City receives $400K grant to build Indigenous Carving Centre in South Surrey

Construction of showcase venue to be completed mid-2022

Snowfall warnings Thursday, Feb. 25, 2021 for parts of the Fraser Valley and Fraser Canyon. (Jennifer Feinberg/The Chilliwack Progress)
Winter storm warnings Thursday for Fraser Valley and Fraser Canyon

Snow is expected to become heavier as day progresses with snowfall amounts of up to 30 centimetres

Longtime basketball coach Allison McNeill is worried that the COVID-19 pandemic will adversely affect high-school athletes with university athletic aspirations. (Garrett James/Langley Events Centre photo)
COVID-19: Young athletes scrambling for scholarships, opportunities amid pandemic

‘They lost their whole Grade 12 year’ says Semiahmoo basketball coach Allison McNeill

When his owner had knee surgery, Kevin, 2, was able to continue to go for walks thanks to volunteers from Elder Dog Canada. (Contributed photo)
White Rock woman among dozens in Lower Mainland to benefit from Elder Dog program

Dog-care organization has a fleet of volunteer walkers ready, but requires more clients to serve

Travis Selje with Rex, the family dog he got to enjoy for the final six months of his life. (Submitted photo)
Defence says evidence ‘compelling, overwhelming’ to acquit Surrey woman in deadly crash

Epileptic seizure caused fatal crash that killed Travis Selje, lawyer argues in final submissions

Dr. Bonnie Henry talk about the next steps in B.C.'s COVID-19 Immunization Plan during a press conference at Legislature in Victoria, B.C., on Friday, January 22, 2021. THE CANADIAN PRESS/Chad Hipolito
456 new COVID-19 cases in B.C., 2 deaths

Since January 2020, 78,278 have tested positive for the novel coronavirus in B.C.

“Support your city” reads a piece of graffiti outside the Ministry of Finance office. (Jane Skrypnek/News Staff)
Slew of anti-bylaw graffiti ‘unacceptable’ says Victoria mayor, police

Downtown businesses, bylaw office and Ministry of Finance vandalized Wednesday morning

A health-care worker prepares a dose of the Pfizer-BioNTech COVID-19 vaccine at a UHN COVID-19 vaccine clinic in Toronto on Thursday, January 7, 2021. (THE CANADIAN PRESS/Nathan Denette)
Vaccinating essential workers before seniors in B.C. could save lives: experts

A new study says the switch could also save up to $230 million in provincial health-care costs

Cannabis bought in British Columbia (Ashley Wadhwani/Black Press Media)
Is it time to start thinking about greener ways to package cannabis?

Packaging suppliers are still figuring eco-friendly and affordable packaging options that fit the mandates of Cannabis Regulations

The late Michael Gregory, 57, is accused of sexually exploiting six junior high students between 1999 and 2005. (Pixabay)
Former Alberta teacher accused of sexually assaulting students found dead in B.C.

Mounties say Michael Gregory’s death has been deemed ‘non-suspicious’

A woman boards a transit bus through rear doors, in Vancouver, on Friday, March 20, 2020. THE CANADIAN PRESS/Darryl Dyck
TransLink slow to reveal crucial details about ransomware attack, says union

Union says company took months to admit what info was stolen, including SIN and bank account details

According to a new poll, a majority of Canadians want to see illicit drugs decriminalized. (THE ASSOCIATED PRESS)
Majority of Canadians think it’s high time to decriminalize illicit drugs: poll

More than two-times the B.C. residents know someone who died from an overdose compared to rest of Canada

Photograph By @KAYLAXANDERSON
VIDEO: Lynx grabs lunch in Kamloops

A lynx surprises a group of ducks and picks one off for lunch

Most Read